多模式学习，尤其是大规模的多模式预训练，在过去的几年中已经迅速发展，并带来了人工智能（AI）的最大进步。尽管具有有效性，但了解多模式预训练模型的潜在机制仍然是一个巨大的挑战。揭示此类模型的解释性可能会使AI领域中新型学习范式的突破。为此，鉴于人脑的多模式性质，我们建议借助非侵入性脑成像技术（例如功能磁共振成像（fMRI））探索多模式学习模型的解释性。具体而言，我们首先提出了1500万个图像文本对预训练的新设计的多模式基础模型，该模型在各种认知下游任务中显示出强烈的多模式理解和概括能力。此外，从神经编码的角度来看（基于我们的基础模型），我们发现，与单峰相比，经过多模式训练的视觉和舌编码器都更像脑状。特别是，我们确定了许多大脑区域，其中多模式训练的编码器表现出更好的神经编码性能。这与现有有关探索大脑多感觉整合的研究的发现是一致的。因此，我们认为，多模式基础模型是神经科学家研究人脑中多模式信号处理机制的更合适的工具。我们的发现还证明了多模式基础模型作为理想的计算模拟器的潜力，以促进脑和大脑的AI研究。

在胸部X射线图像中定位疾病很少仔细注释可以节省大量的人类努力。最近的作品通过创新的弱监督算法（例如多稳定学习（MIL）和类激活图（CAM））处理了这项任务，但是，这些方法通常会产生不准确或不完整的区域。原因之一是忽视了每个图像内部解剖区域的关系中隐藏的病理意义以及跨图像的关系。在本文中，我们认为，作为上下文和补偿信息的跨区域和跨图像关系对于获得更一致和更一致的区域至关重要。为了建模关系，我们提出了图形正则嵌入网络（GREN），该网络（GREN）利用图像和图像间信息来定位胸部X射线图像上的疾病。 Gren使用预先训练的U-NET来分割肺裂片，然后使用图像内图形图对肺裂片之间的内图像进行建模以比较不同的区域。同时，内部图像之间的关系是通过图像间图建模的，以比较多个图像。此过程模仿了放射科医生的训练和决策过程：比较多个区域和图像进行诊断。为了使神经网络的深层嵌入层保留结构信息（在本地化任务中很重要），我们使用哈希编码和锤击距离来计算图形，这些图形用作正规化器来促进训练。通过这种情况，我们的方法实现了NIH胸部X射线数据集的最新结果，以实现弱监督疾病的定位。我们的代码可在线访问（https://github.com/qibaolian/gren）。

Learning the underlying distribution of molecular graphs and generating high-fidelity samples is a fundamental research problem in drug discovery and material science. However, accurately modeling distribution and rapidly generating novel molecular graphs remain crucial and challenging goals. To accomplish these goals, we propose a novel Conditional Diffusion model based on discrete Graph Structures (CDGS) for molecular graph generation. Specifically, we construct a forward graph diffusion process on both graph structures and inherent features through stochastic differential equations (SDE) and derive discrete graph structures as the condition for reverse generative processes. We present a specialized hybrid graph noise prediction model that extracts the global context and the local node-edge dependency from intermediate graph states. We further utilize ordinary differential equation (ODE) solvers for efficient graph sampling, based on the semi-linear structure of the probability flow ODE. Experiments on diverse datasets validate the effectiveness of our framework. Particularly, the proposed method still generates high-quality molecular graphs in a limited number of steps.

High-utility sequential pattern mining (HUSPM) has emerged as an important topic due to its wide application and considerable popularity. However, due to the combinatorial explosion of the search space when the HUSPM problem encounters a low utility threshold or large-scale data, it may be time-consuming and memory-costly to address the HUSPM problem. Several algorithms have been proposed for addressing this problem, but they still cost a lot in terms of running time and memory usage. In this paper, to further solve this problem efficiently, we design a compact structure called sequence projection (seqPro) and propose an efficient algorithm, namely discovering high-utility sequential patterns with the seqPro structure (HUSP-SP). HUSP-SP utilizes the compact seq-array to store the necessary information in a sequence database. The seqPro structure is designed to efficiently calculate candidate patterns' utilities and upper bound values. Furthermore, a new upper bound on utility, namely tighter reduced sequence utility (TRSU) and two pruning strategies in search space, are utilized to improve the mining performance of HUSP-SP. Experimental results on both synthetic and real-life datasets show that HUSP-SP can significantly outperform the state-of-the-art algorithms in terms of running time, memory usage, search space pruning efficiency, and scalability.

Graph Neural Networks (GNNs) have become increasingly important in recent years due to their state-of-the-art performance on many important downstream applications. Existing GNNs have mostly focused on learning a single node representation, despite that a node often exhibits polysemous behavior in different contexts. In this work, we develop a persona-based graph neural network framework called PersonaSAGE that learns multiple persona-based embeddings for each node in the graph. Such disentangled representations are more interpretable and useful than a single embedding. Furthermore, PersonaSAGE learns the appropriate set of persona embeddings for each node in the graph, and every node can have a different number of assigned persona embeddings. The framework is flexible enough and the general design helps in the wide applicability of the learned embeddings to suit the domain. We utilize publicly available benchmark datasets to evaluate our approach and against a variety of baselines. The experiments demonstrate the effectiveness of PersonaSAGE for a variety of important tasks including link prediction where we achieve an average gain of 15% while remaining competitive for node classification. Finally, we also demonstrate the utility of PersonaSAGE with a case study for personalized recommendation of different entity types in a data management platform.

With the development of natural language processing techniques(NLP), automatic diagnosis of eye diseases using ophthalmology electronic medical records (OEMR) has become possible. It aims to evaluate the condition of both eyes of a patient respectively, and we formulate it as a particular multi-label classification task in this paper. Although there are a few related studies in other diseases, automatic diagnosis of eye diseases exhibits unique characteristics. First, descriptions of both eyes are mixed up in OEMR documents, with both free text and templated asymptomatic descriptions, resulting in sparsity and clutter of information. Second, OEMR documents contain multiple parts of descriptions and have long document lengths. Third, it is critical to provide explainability to the disease diagnosis model. To overcome those challenges, we present an effective automatic eye disease diagnosis framework, NEEDED. In this framework, a preprocessing module is integrated to improve the density and quality of information. Then, we design a hierarchical transformer structure for learning the contextualized representations of each sentence in the OEMR document. For the diagnosis part, we propose an attention-based predictor that enables traceable diagnosis by obtaining disease-specific information. Experiments on the real dataset and comparison with several baseline models show the advantage and explainability of our framework.

Because of the necessity to obtain high-quality images with minimal radiation doses, such as in low-field magnetic resonance imaging, super-resolution reconstruction in medical imaging has become more popular (MRI). However, due to the complexity and high aesthetic requirements of medical imaging, image super-resolution reconstruction remains a difficult challenge. In this paper, we offer a deep learning-based strategy for reconstructing medical images from low resolutions utilizing Transformer and Generative Adversarial Networks (T-GAN). The integrated system can extract more precise texture information and focus more on important locations through global image matching after successfully inserting Transformer into the generative adversarial network for picture reconstruction. Furthermore, we weighted the combination of content loss, adversarial loss, and adversarial feature loss as the final multi-task loss function during the training of our proposed model T-GAN. In comparison to established measures like PSNR and SSIM, our suggested T-GAN achieves optimal performance and recovers more texture features in super-resolution reconstruction of MRI scanned images of the knees and belly.

In this paper, we target at the problem of learning a generalizable dynamic radiance field from monocular videos. Different from most existing NeRF methods that are based on multiple views, monocular videos only contain one view at each timestamp, thereby suffering from ambiguity along the view direction in estimating point features and scene flows. Previous studies such as DynNeRF disambiguate point features by positional encoding, which is not transferable and severely limits the generalization ability. As a result, these methods have to train one independent model for each scene and suffer from heavy computational costs when applying to increasing monocular videos in real-world applications. To address this, We propose MonoNeRF to simultaneously learn point features and scene flows with point trajectory and feature correspondence constraints across frames. More specifically, we learn an implicit velocity field to estimate point trajectory from temporal features with Neural ODE, which is followed by a flow-based feature aggregation module to obtain spatial features along the point trajectory. We jointly optimize temporal and spatial features by training the network in an end-to-end manner. Experiments show that our MonoNeRF is able to learn from multiple scenes and support new applications such as scene editing, unseen frame synthesis, and fast novel scene adaptation.

Feedforward fully convolutional neural networks currently dominate in semantic segmentation of 3D point clouds. Despite their great success, they suffer from the loss of local information at low-level layers, posing significant challenges to accurate scene segmentation and precise object boundary delineation. Prior works either address this issue by post-processing or jointly learn object boundaries to implicitly improve feature encoding of the networks. These approaches often require additional modules which are difficult to integrate into the original architecture. To improve the segmentation near object boundaries, we propose a boundary-aware feature propagation mechanism. This mechanism is achieved by exploiting a multi-task learning framework that aims to explicitly guide the boundaries to their original locations. With one shared encoder, our network outputs (i) boundary localization, (ii) prediction of directions pointing to the object's interior, and (iii) semantic segmentation, in three parallel streams. The predicted boundaries and directions are fused to propagate the learned features to refine the segmentation. We conduct extensive experiments on the S3DIS and SensatUrban datasets against various baseline methods, demonstrating that our proposed approach yields consistent improvements by reducing boundary errors. Our code is available at https://github.com/shenglandu/PushBoundary.

Real estate appraisal is a crucial issue for urban applications, which aims to value the properties on the market. Traditional methods perform appraisal based on the domain knowledge, but suffer from the efforts of hand-crafted design. Recently, several methods have been developed to automatize the valuation process by taking the property trading transaction into account when estimating the property value. However, existing methods only consider the real estate itself, ignoring the relation between the properties. Moreover, naively aggregating the information of neighbors fails to model the relationships between the transactions. To tackle these limitations, we propose a novel Neighbor Relation Graph Learning Framework (ReGram) by incorporating the relation between target transaction and surrounding neighbors with the attention mechanism. To model the influence between communities, we integrate the environmental information and the past price of each transaction from other communities. Moreover, since the target transactions in different regions share some similarities and differences of characteristics, we introduce a dynamic adapter to model the different distributions of the target transactions based on the input-related kernel weights. Extensive experiments on the real-world dataset with various scenarios demonstrate that ReGram robustly outperforms the state-of-the-art methods. Furthermore, comprehensive ablation studies were conducted to examine the effectiveness of each component in ReGram.